Gottfried Schatz Forschungszentrum | Biophysik

Medizinische Universität Graz

Groschner Lab

Klaus Groschner is pharmacologist and biophysicist, graduated at the School of Pharmacy, University of Graz, Austria. He completed his PhD studies at the Department of Pharmacodynamics in Graz and received part of his postdoctoral training at the University of Miami, Florida, USA, studying electrophysiology and cell biology. In 1990 he became an Research Assistant at the Department of Pharmacology and Toxicology and in 1993 Assistant Professor in Pharmacology and Toxicology (Habilitation) at the University of Graz and subsequently, in 1997 Associate Professor at the Institute for Pharmaceutical Sciences (University of Graz) directing the research group for Physiology and Pathophysiology of Membrane Transport. Since 2012, he is appointed as a Full Professor and Chair of Biophysics at the Gottfried-Schatz-Research Center of the Medical University of Graz. His research is focused on Cell Biology, Synthetic Biology and Pharmacology of Transient Receptor Potential (TRP) channels.

Research interest:

Long term research focus of the laboratory is Biophysics and Molecular (Patho)physiology of ion channels and transporters. The group aims at understanding structure-function relations in canonical (C-type) transient receptor potential (TRPC) channels and store-operated (Orai) channels with particular attention to the function of these channel complexes in native tissues and their response to environmental stress. Ongoing projects address the function of TRPC and Orai channels as sensors for lipid mediators. Recently, the laboratory has focused on photopharmacological and opto-chemogenetic approaches. This technology allows for exceptionally high spatiotemporal precision in controlling signaling molecules and is expected to provide deep insight into their function and pathophysiology. Recent development of lipid photoswitches provided understanding diacylglycerol (DAG) recognition by ion channels. Innovative photopharmacological and opto-chemogenetic approaches are now available to investigate principles of dysregulation of and maladaptive responses mediated by TRPC and other DAG-controlled channels in native tissues. Current projects utilize novel molecular probes, transgenic animal models and opto-chemogenetic strategies for in depth investigations of the role of TRPC channels in vascular endothelial, immune and cancer cells.

Current topics/projects:

  • Lipid recognition/sensing in Ion channels (TRPC)
  • Celltype-specific signaling of TRPC channels
  • Signal processing in ER-PM nanojunctions
  • Opto-chemogenetic of lipid-regulated channels

 

Optocal interrogation of lipid gating in ion channels (Nat Chem Biol. 2018; 14, 396-404)

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